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Advancing a new generation
of fine-tuned neuromedicines

Our platform enables us to develop novel, differentiated GABAA positive allosteric modulators to precisely treat neurological disorders like Essential Tremor, epilepsy and anxiety

Vision
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Pagliuca
Harvard
Life Lab

OUR STORY

Our team has dedicated their careers to neuromedicine. We coalesced to advance scientific innovations that help patients with neurological disorders live longer, healthier lives.

The idea was born at Prof. Kevin Hodgetts' Laboratory for Drug Discovery in Neuroscience at the Brigham and Women's Hospital, when Dr. Hodgetts and Dr. Dario Doller saw the opportunity to harness allosteric modulation to develop a new generation of GABAA small molecule therapies.

We are now advancing small molecules to treat Essential Tremor (ET), epilepsy, anxiety, and other neurological disorders.
 

Our methodology

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Next-gen

We are building on 160+ years of GABAA research to develop next-gen, differentiated GABAA PAMs that provide efficacy without side-effects.

Translatable

We focus on validated biological targets, with strong translational assays and efficient route to clinical proof-of-mechanism where current treatments fail to address patient needs.

Fine-Tuned

Our lead small molecules are fine-tuned GABAA modulators that can restore healthy receptor function while avoiding over-activation.

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Our First Therapies

We have achieved in vivo proof-of-concept in mice, and are close to identifying a development candidate to treat Essential Tremor. 
 

Our compounds show strong activity in epilepsy models, which we are scaling up

Brain Scans

Meet the Team

We have dedicated our careers to advancing scientific innovations to help patients live longer, healthier lives.

Our Scientific Advisory Board

Our team has developed 50+ clinical and 10 marketed drugs

Recognitions

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Nucleate Venture Prize

Awarded pre-seed funding from Pillar VC via NVP, 1 of 200 teams

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Blavatnik Therapeutics Grant

Founding lab supported by Blavatnik grant funding for this project from 2022-2024

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Harvard Business School

Semi-finalists in the 2023 HBS NVC pitch competition

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Nucleate Activator Program

Semi-finalists in the 2023 Nucleate Activator Program final pitch showcase in Boston

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iLab Grant Award

Awarded grant funding by the iLab in 2023 and 2024

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Harvard Innovation Lab

Semi-finalists 2023 and
Finalists 2024 in the Harvard iLab’s PIC, 5 of 400+ teams

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MIT SHIP Competition

Semi-finalists in the 2024 MIT SHIP competition, 8 of 300+ teams

Current treatments are worse than the disease itself

- Patients, physicians and caregivers struggling with Essential Tremor (ET)

Indication #1: Essential Tremor

Essential Tremor is widespread and highly debilitating

Yet ET remains significantly underreported and undertreated

We are thrilled to advance the first novel treatment to help ET patients, their families and caretakers in over half a century.

Please connect to learn more - we are excited to engage with the ET community!

Get in Touch

Modulate Bio

Pagliuca Harvard Life Lab 

127 Western Avenue, Allston, MA 02134

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