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Unlocking a new generation
of precision neuro-medicines

Our platform enables us to precisely treat neurological disorders like Essential Tremor, epilepsy and anxiety by restoring healthy brain receptor function, without overactivating

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Life Lab


Our team has dedicated their careers to developing neuro-medicines for patients. We coalesced to advance scientific innovations that help patients with neurological disorders live longer, healthier lives.

The idea was born at Prof. Kevin Hodgetts' Laboratory for Drug Discovery in Neuroscience at the Brigham and Women's Hospital, when Dr. Hodgetts and Dr. Dario Doller saw the opportunity to harness allosteric modulation to develop a new generation of neurological therapies.

We are now advancing a small molecule therapy to treat Essential Tremor (ET), then targeting epilepsy, anxiety, and other neurological disorders.

Our methodology


Next-gen Platform

Our platform unravels how compounds mechanistically interact with brain receptors and can be iteratively refined to treat specific diseases. 


We focus on validated biological targets, with strong translational assays and efficient route to clinical proof-of-mechanism where current treatments fail to address patient needs.

Patients First

Our lead small molecule is a GABAA modulator, fine-tuned to restore healthy receptor function while avoiding over-activation, to provide efficacy with reduced side-effects

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Our First Therapy

We have achieved in vivo proof-of-concept in mice, and are close to identifying a development candidate to treat Essential Tremor.

Brain Scans

Meet the Team

We have dedicated our careers to advancing scientific innovations to help patients live longer, healthier lives.

Our Scientific Advisory Board

Our team has developed 50+ clinical and 10 marketed drugs


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Nucleate Venture Prize

Awarded pre-seed funding from Pillar VC via NVP, 1 of 200 teams

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Blavatnik Therapeutics Grant

Founding lab supported by Blavatnik grant funding for this project from 2022-2024


Harvard Business School

Semi-finalists in the 2023 HBS NVC pitch competition

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Nucleate Activator Program

Semi-finalists in the 2023 Nucleate Activator Program final pitch showcase in Boston


iLab Grant Award

Awarded grant funding by the iLab in 2023 and 2024


Harvard Innovation Lab

Semi-finalists 2023 and
Finalists 2024 in the Harvard iLab’s PIC, 5 of 400+ teams

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MIT SHIP Competition

Semi-finalists in the 2024 MIT SHIP competition, 8 of 300+ teams

Current treatments are worse than the disease itself

- Patients, physicians and caregivers struggling with Essential Tremor (ET)

Indication #1: Essential Tremor

Essential Tremor is widespread and highly debilitating

Yet ET remains significantly underreported and undertreated

We are thrilled to advance the first novel treatment to help ET patients, their families and caretakers in over half a century.

Please connect to learn more - we are excited to engage with the ET community!

Get in Touch

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Pagliuca Harvard Life Lab 

127 Western Avenue, Allston, MA 02134

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